Graphical Abstract. Credit: Chem (2023). DOI: 10.1016/j.chempr.2022.12.019
Substituted aromatics are among the most important building blocks for organic compounds such as drugs, crop-protecting agents, and many materials. The function of the molecules is determined by the spatial arrangement of the different building blocks, the substitution pattern.
A research team from the Otto Diels Institute of Organic Chemistry at Kiel University has now presented a method in the journal Chem to produce compounds with a particularly attractive but typically challenging to access substitution pattern, more efficiently than before. To enable the required activation of carbon-hydrogen (C-H) bonds, they…